ENTECAVIR



Mechanism


Entecavir is a nucleosides ( contain nucleic acid and a sugar) or deoxyguanosine which belongs to carbocyclic nucleosides class thereby prevent reverse transcription, DNA reproduction and transcription in the viral replication process.

Entecavir also contain other nucleoside and nucleotide analogues include lamivudine, telbivudine, dipivoxil, tenofovir,adefovir. Baraclude decrease the amount of HBV in the blood in which lowers the ability of multiply and infect new cells.

After Lamivudine and emtricitabine resistance in HIV may select the Entecavir drug. Entecavir is well controlled treatment for HBV and its effective while taking by mouth. There is no currently sufficient and well tolerated studies present in pregnant women (belongs to category C).

Combination of Entecavir with other regimen will decrease kidney function or finish the active tubular secretion may increase serum concentration of either Entecavir or the other drug combination. There is no important interaction between drugs lamivudine,adeforvir,dipivoxil or tenofovir with Entecavir.

Administration

It is through oral cavity (mouth) as a solution or tablet. The dosage of the medicine is depends on individual person’s weight:

Children more than 2 yrs old( weigh up to 30kg), the dose recommended is solution. Entecavir is effective on empty stomach 2 hours before or after a meal, same time each day. According to kidney function decreasing the dose adjustment is recommended for people. Entecavir is not recommended for children <2yrs.

Medical used mainly in adult and > 2yrs children for treatment of chronic hepatitis B infection by active viral multiplication and indication of active disease with risein liver enzyme. Entecavir is also used to inhibits HBV reinfection after liver transplant and to treat the HBV infected in HIV patients. Entecavir has less action against HIV,hence it is not prescribed for the patient who co- infected with HIV-HBV without repressive anti-HIV drugs.

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Warning

When use of nucleoside analogues alone or with combination of antiretroviral ,the lactic acidosis and severe heptomegaly with steatosis involves in reporting fatal cases.

Discontinuation of anti hepatitis therapy which leads to severe acute exacerbations of hepatitis B have been reported In pregnancy category, proper care should be taken due to no data available on tranamission of HBV from mother to infant by the Entecavir drug effect.

If patient under treatment of Entecavir, avoid breast feeding.

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Side effects of Entecavir

• Vomit sensation
• Vertigo
• Weakness
• Head pain
• Sleeping trouble

Storage

• Keep in cool and dry place.
• Protect from moisture and light.
• Keep out of the children reach.

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